yaps127a plasmid Search Results


yap pt3 ef1a flag yaps127a addgene plasmid 46049  (Addgene inc)
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Addgene inc yap pt3 ef1a flag yaps127a addgene plasmid 46049
Yap Pt3 Ef1a Flag Yaps127a Addgene Plasmid 46049, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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yap pt3 ef1a flag yaps127a addgene plasmid 46049 - by Bioz Stars, 2026-08
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plasmid yaps127a  (Addgene inc)
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Addgene inc plasmid yaps127a
Fig. 7. In vivo activation of YAP in hepatocytes led to transdifferentiation upon alcohol exposure, and blocked hepatocyte proliferation after CCl4-induced injury. (A) Representative YAP and SOX9 immunostaining experiments (magnification x200). (B) A histogram representing liver Sox9 and Hnf1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significance is indicated. (C) Representative H&E histological picture of livers obtained from CD, LDC, <t>YAPS127A-CD</t> and YAPS127A-LDC mice (x200). Yellow arrowheads indicate the inflammatory infiltrates and dashed lines delineate areas of liver necrosis. (D) A histogram representing liver Tnfa and Il1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significances are indicated (Mann-Whitney U test). (E) Immunostaining evaluating BrdU incorporation 48 h after CCl4 intoxication in mice treated with CCl4 and injected with an irrelevant AAV (CCl4) or AAV2/8-YAPS127A (CCl4+YAPS127A). Arrowheads: BrdU-positive hepatocytes. (F) A histogram representing the BrdU-positive cell count 48 h after CCl4 injection in mice. The results are expressed as the mean ± SD number of BrdU-positive hepatocytes per mm2. (G) A histogram representing liver Sox9 and Hnf1b mRNA expression in mouse livers. The results are expressed in relative units (mean ± SD), and the statistical sig- nificances are indicated (Mann-Whitney U test). AAV, adeno-associated virus; CCl4, carbon tetrachloride; DC, Lieber de Carli.
Plasmid Yaps127a, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/yaps127a+plasmid/pm34129887-67-12-14?v=Addgene+inc
Average 93 stars, based on 1 article reviews
plasmid yaps127a - by Bioz Stars, 2026-08
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megfp n1 yaps127a l318e plasmid  (Addgene inc)
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Addgene inc megfp n1 yaps127a l318e plasmid
Fig. 7. In vivo activation of YAP in hepatocytes led to transdifferentiation upon alcohol exposure, and blocked hepatocyte proliferation after CCl4-induced injury. (A) Representative YAP and SOX9 immunostaining experiments (magnification x200). (B) A histogram representing liver Sox9 and Hnf1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significance is indicated. (C) Representative H&E histological picture of livers obtained from CD, LDC, <t>YAPS127A-CD</t> and YAPS127A-LDC mice (x200). Yellow arrowheads indicate the inflammatory infiltrates and dashed lines delineate areas of liver necrosis. (D) A histogram representing liver Tnfa and Il1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significances are indicated (Mann-Whitney U test). (E) Immunostaining evaluating BrdU incorporation 48 h after CCl4 intoxication in mice treated with CCl4 and injected with an irrelevant AAV (CCl4) or AAV2/8-YAPS127A (CCl4+YAPS127A). Arrowheads: BrdU-positive hepatocytes. (F) A histogram representing the BrdU-positive cell count 48 h after CCl4 injection in mice. The results are expressed as the mean ± SD number of BrdU-positive hepatocytes per mm2. (G) A histogram representing liver Sox9 and Hnf1b mRNA expression in mouse livers. The results are expressed in relative units (mean ± SD), and the statistical sig- nificances are indicated (Mann-Whitney U test). AAV, adeno-associated virus; CCl4, carbon tetrachloride; DC, Lieber de Carli.
Megfp N1 Yaps127a L318e Plasmid, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/yaps127a+plasmid/pmc10897393-267-23-25?v=Addgene+inc
Average 93 stars, based on 1 article reviews
megfp n1 yaps127a l318e plasmid - by Bioz Stars, 2026-08
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yaps127a megfp plasmids  (Addgene inc)
94
Addgene inc yaps127a megfp plasmids
Fig. 7. In vivo activation of YAP in hepatocytes led to transdifferentiation upon alcohol exposure, and blocked hepatocyte proliferation after CCl4-induced injury. (A) Representative YAP and SOX9 immunostaining experiments (magnification x200). (B) A histogram representing liver Sox9 and Hnf1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significance is indicated. (C) Representative H&E histological picture of livers obtained from CD, LDC, <t>YAPS127A-CD</t> and YAPS127A-LDC mice (x200). Yellow arrowheads indicate the inflammatory infiltrates and dashed lines delineate areas of liver necrosis. (D) A histogram representing liver Tnfa and Il1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significances are indicated (Mann-Whitney U test). (E) Immunostaining evaluating BrdU incorporation 48 h after CCl4 intoxication in mice treated with CCl4 and injected with an irrelevant AAV (CCl4) or AAV2/8-YAPS127A (CCl4+YAPS127A). Arrowheads: BrdU-positive hepatocytes. (F) A histogram representing the BrdU-positive cell count 48 h after CCl4 injection in mice. The results are expressed as the mean ± SD number of BrdU-positive hepatocytes per mm2. (G) A histogram representing liver Sox9 and Hnf1b mRNA expression in mouse livers. The results are expressed in relative units (mean ± SD), and the statistical sig- nificances are indicated (Mann-Whitney U test). AAV, adeno-associated virus; CCl4, carbon tetrachloride; DC, Lieber de Carli.
Yaps127a Megfp Plasmids, supplied by Addgene inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/yaps127a+plasmid/pm33606996-308-3-21?v=Addgene+inc
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yaps127a megfp plasmids - by Bioz Stars, 2026-08
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pt3 ef1a yaps127a  (Addgene inc)
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Fig. 7. In vivo activation of YAP in hepatocytes led to transdifferentiation upon alcohol exposure, and blocked hepatocyte proliferation after CCl4-induced injury. (A) Representative YAP and SOX9 immunostaining experiments (magnification x200). (B) A histogram representing liver Sox9 and Hnf1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significance is indicated. (C) Representative H&E histological picture of livers obtained from CD, LDC, <t>YAPS127A-CD</t> and YAPS127A-LDC mice (x200). Yellow arrowheads indicate the inflammatory infiltrates and dashed lines delineate areas of liver necrosis. (D) A histogram representing liver Tnfa and Il1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significances are indicated (Mann-Whitney U test). (E) Immunostaining evaluating BrdU incorporation 48 h after CCl4 intoxication in mice treated with CCl4 and injected with an irrelevant AAV (CCl4) or AAV2/8-YAPS127A (CCl4+YAPS127A). Arrowheads: BrdU-positive hepatocytes. (F) A histogram representing the BrdU-positive cell count 48 h after CCl4 injection in mice. The results are expressed as the mean ± SD number of BrdU-positive hepatocytes per mm2. (G) A histogram representing liver Sox9 and Hnf1b mRNA expression in mouse livers. The results are expressed in relative units (mean ± SD), and the statistical sig- nificances are indicated (Mann-Whitney U test). AAV, adeno-associated virus; CCl4, carbon tetrachloride; DC, Lieber de Carli.
Pt3 Ef1a Yaps127a, supplied by Addgene inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/yaps127a+plasmid/10__1158_slash_2159___8290__cd___21___1640-324-43-45?v=Addgene+inc
Average 94 stars, based on 1 article reviews
pt3 ef1a yaps127a - by Bioz Stars, 2026-08
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yaps127a plasmid  (Addgene inc)
93
Addgene inc yaps127a plasmid
Fig. 7. In vivo activation of YAP in hepatocytes led to transdifferentiation upon alcohol exposure, and blocked hepatocyte proliferation after CCl4-induced injury. (A) Representative YAP and SOX9 immunostaining experiments (magnification x200). (B) A histogram representing liver Sox9 and Hnf1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significance is indicated. (C) Representative H&E histological picture of livers obtained from CD, LDC, <t>YAPS127A-CD</t> and YAPS127A-LDC mice (x200). Yellow arrowheads indicate the inflammatory infiltrates and dashed lines delineate areas of liver necrosis. (D) A histogram representing liver Tnfa and Il1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significances are indicated (Mann-Whitney U test). (E) Immunostaining evaluating BrdU incorporation 48 h after CCl4 intoxication in mice treated with CCl4 and injected with an irrelevant AAV (CCl4) or AAV2/8-YAPS127A (CCl4+YAPS127A). Arrowheads: BrdU-positive hepatocytes. (F) A histogram representing the BrdU-positive cell count 48 h after CCl4 injection in mice. The results are expressed as the mean ± SD number of BrdU-positive hepatocytes per mm2. (G) A histogram representing liver Sox9 and Hnf1b mRNA expression in mouse livers. The results are expressed in relative units (mean ± SD), and the statistical sig- nificances are indicated (Mann-Whitney U test). AAV, adeno-associated virus; CCl4, carbon tetrachloride; DC, Lieber de Carli.
Yaps127a Plasmid, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/yaps127a+plasmid/pmc08178191-100-1-3?v=Addgene+inc
Average 93 stars, based on 1 article reviews
yaps127a plasmid - by Bioz Stars, 2026-08
93/100 stars
  Buy from Supplier
pt3 ef1a yaps127a addgene  (Addgene inc)
94
Addgene inc pt3 ef1a yaps127a addgene
Fig. 7. In vivo activation of YAP in hepatocytes led to transdifferentiation upon alcohol exposure, and blocked hepatocyte proliferation after CCl4-induced injury. (A) Representative YAP and SOX9 immunostaining experiments (magnification x200). (B) A histogram representing liver Sox9 and Hnf1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significance is indicated. (C) Representative H&E histological picture of livers obtained from CD, LDC, <t>YAPS127A-CD</t> and YAPS127A-LDC mice (x200). Yellow arrowheads indicate the inflammatory infiltrates and dashed lines delineate areas of liver necrosis. (D) A histogram representing liver Tnfa and Il1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significances are indicated (Mann-Whitney U test). (E) Immunostaining evaluating BrdU incorporation 48 h after CCl4 intoxication in mice treated with CCl4 and injected with an irrelevant AAV (CCl4) or AAV2/8-YAPS127A (CCl4+YAPS127A). Arrowheads: BrdU-positive hepatocytes. (F) A histogram representing the BrdU-positive cell count 48 h after CCl4 injection in mice. The results are expressed as the mean ± SD number of BrdU-positive hepatocytes per mm2. (G) A histogram representing liver Sox9 and Hnf1b mRNA expression in mouse livers. The results are expressed in relative units (mean ± SD), and the statistical sig- nificances are indicated (Mann-Whitney U test). AAV, adeno-associated virus; CCl4, carbon tetrachloride; DC, Lieber de Carli.
Pt3 Ef1a Yaps127a Addgene, supplied by Addgene inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/yaps127a+plasmid/pm34352206-265-14-15?v=Addgene+inc
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pt3 ef1a yaps127a addgene - by Bioz Stars, 2026-08
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megfp n1 yaps127a plasmids  (Addgene inc)
93
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Fig. 7. In vivo activation of YAP in hepatocytes led to transdifferentiation upon alcohol exposure, and blocked hepatocyte proliferation after CCl4-induced injury. (A) Representative YAP and SOX9 immunostaining experiments (magnification x200). (B) A histogram representing liver Sox9 and Hnf1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significance is indicated. (C) Representative H&E histological picture of livers obtained from CD, LDC, <t>YAPS127A-CD</t> and YAPS127A-LDC mice (x200). Yellow arrowheads indicate the inflammatory infiltrates and dashed lines delineate areas of liver necrosis. (D) A histogram representing liver Tnfa and Il1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significances are indicated (Mann-Whitney U test). (E) Immunostaining evaluating BrdU incorporation 48 h after CCl4 intoxication in mice treated with CCl4 and injected with an irrelevant AAV (CCl4) or AAV2/8-YAPS127A (CCl4+YAPS127A). Arrowheads: BrdU-positive hepatocytes. (F) A histogram representing the BrdU-positive cell count 48 h after CCl4 injection in mice. The results are expressed as the mean ± SD number of BrdU-positive hepatocytes per mm2. (G) A histogram representing liver Sox9 and Hnf1b mRNA expression in mouse livers. The results are expressed in relative units (mean ± SD), and the statistical sig- nificances are indicated (Mann-Whitney U test). AAV, adeno-associated virus; CCl4, carbon tetrachloride; DC, Lieber de Carli.
Megfp N1 Yaps127a Plasmids, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/yaps127a+plasmid/bio_rxiv__2025__11__20__689524-37-8-13?v=Addgene+inc
Average 93 stars, based on 1 article reviews
megfp n1 yaps127a plasmids - by Bioz Stars, 2026-08
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plasmid yaps127a flag  (Addgene inc)
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Fig. 7. In vivo activation of YAP in hepatocytes led to transdifferentiation upon alcohol exposure, and blocked hepatocyte proliferation after CCl4-induced injury. (A) Representative YAP and SOX9 immunostaining experiments (magnification x200). (B) A histogram representing liver Sox9 and Hnf1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significance is indicated. (C) Representative H&E histological picture of livers obtained from CD, LDC, <t>YAPS127A-CD</t> and YAPS127A-LDC mice (x200). Yellow arrowheads indicate the inflammatory infiltrates and dashed lines delineate areas of liver necrosis. (D) A histogram representing liver Tnfa and Il1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significances are indicated (Mann-Whitney U test). (E) Immunostaining evaluating BrdU incorporation 48 h after CCl4 intoxication in mice treated with CCl4 and injected with an irrelevant AAV (CCl4) or AAV2/8-YAPS127A (CCl4+YAPS127A). Arrowheads: BrdU-positive hepatocytes. (F) A histogram representing the BrdU-positive cell count 48 h after CCl4 injection in mice. The results are expressed as the mean ± SD number of BrdU-positive hepatocytes per mm2. (G) A histogram representing liver Sox9 and Hnf1b mRNA expression in mouse livers. The results are expressed in relative units (mean ± SD), and the statistical sig- nificances are indicated (Mann-Whitney U test). AAV, adeno-associated virus; CCl4, carbon tetrachloride; DC, Lieber de Carli.
Plasmid Yaps127a Flag, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Fig. 7. In vivo activation of YAP in hepatocytes led to transdifferentiation upon alcohol exposure, and blocked hepatocyte proliferation after CCl4-induced injury. (A) Representative YAP and SOX9 immunostaining experiments (magnification x200). (B) A histogram representing liver Sox9 and Hnf1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significance is indicated. (C) Representative H&E histological picture of livers obtained from CD, LDC, YAPS127A-CD and YAPS127A-LDC mice (x200). Yellow arrowheads indicate the inflammatory infiltrates and dashed lines delineate areas of liver necrosis. (D) A histogram representing liver Tnfa and Il1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significances are indicated (Mann-Whitney U test). (E) Immunostaining evaluating BrdU incorporation 48 h after CCl4 intoxication in mice treated with CCl4 and injected with an irrelevant AAV (CCl4) or AAV2/8-YAPS127A (CCl4+YAPS127A). Arrowheads: BrdU-positive hepatocytes. (F) A histogram representing the BrdU-positive cell count 48 h after CCl4 injection in mice. The results are expressed as the mean ± SD number of BrdU-positive hepatocytes per mm2. (G) A histogram representing liver Sox9 and Hnf1b mRNA expression in mouse livers. The results are expressed in relative units (mean ± SD), and the statistical sig- nificances are indicated (Mann-Whitney U test). AAV, adeno-associated virus; CCl4, carbon tetrachloride; DC, Lieber de Carli.

Journal: Journal of hepatology

Article Title: Loss of hepatocyte identity following aberrant YAP activation: A key mechanism in alcoholic hepatitis.

doi: 10.1016/j.jhep.2021.05.041

Figure Lengend Snippet: Fig. 7. In vivo activation of YAP in hepatocytes led to transdifferentiation upon alcohol exposure, and blocked hepatocyte proliferation after CCl4-induced injury. (A) Representative YAP and SOX9 immunostaining experiments (magnification x200). (B) A histogram representing liver Sox9 and Hnf1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significance is indicated. (C) Representative H&E histological picture of livers obtained from CD, LDC, YAPS127A-CD and YAPS127A-LDC mice (x200). Yellow arrowheads indicate the inflammatory infiltrates and dashed lines delineate areas of liver necrosis. (D) A histogram representing liver Tnfa and Il1b mRNA expression in livers. The results are expressed in relative units (mean ± SEM), and the statistical significances are indicated (Mann-Whitney U test). (E) Immunostaining evaluating BrdU incorporation 48 h after CCl4 intoxication in mice treated with CCl4 and injected with an irrelevant AAV (CCl4) or AAV2/8-YAPS127A (CCl4+YAPS127A). Arrowheads: BrdU-positive hepatocytes. (F) A histogram representing the BrdU-positive cell count 48 h after CCl4 injection in mice. The results are expressed as the mean ± SD number of BrdU-positive hepatocytes per mm2. (G) A histogram representing liver Sox9 and Hnf1b mRNA expression in mouse livers. The results are expressed in relative units (mean ± SD), and the statistical sig- nificances are indicated (Mann-Whitney U test). AAV, adeno-associated virus; CCl4, carbon tetrachloride; DC, Lieber de Carli.

Article Snippet: Briefly, cDNA for the constitutively active human YAP was cloned from the plasmid YAPS127A (Addgene #27370) to the pAAV2 vector plasmid (containing inverted terminal repeats [ITR]-2 from pSub201 plasmid) using specific restriction enzymes (Kpn1/EcoR5) for the pAAV.CMV.YAPS127A construct, which was then subcloned using Not1 to obtain the pAAV.LP1.YAPS127A construct.

Techniques: In Vivo, Activation Assay, Immunostaining, Expressing, MANN-WHITNEY, BrdU Incorporation Assay, Injection, Cell Counting, Virus